Fundamental to the development of the opera was the sustained involvement of patients, healthcare staff, family members, as well as basic & clinical researchers. The librettist & composer visited the biomarkers labs, talked extensively to the various stakeholders and witnessed various practices of dementia care.

The opera premiered at the Brighton Festival in May 2010, and will come to the Linbury Studio at the Royal Opera House, London in July 2010. The opera explores the lifeworlds and current research practices surrounding Alzheimer’s disease, and opens up a variety of questions vis-a-vis how aesthetic projects engage with social scientists, scientists and other stakeholders in the development of creative work that explores biomedical research and practices.

This event seems increadibly interesting (from my point of view investigating neuroscience and concepts of aging), and I certainly wish I was going to London this summer so I could experience it.

It’s not only that it appearently is really good science communication in the sense of communicating the experience and important aspects of a dreaded disease – see Dementia opera so realistic it could be used as teaching aid for medical students – but also that it shows the potential of art as a interactive medium for both public engagement with science and science engagement with public. Which, by the way, is just what I think the ideal medical museum should be!

Recent accounts of the role of science in the development of medical practice have tended to concentrate on instances of tension between scientists and practitioners. This paper revisits the historiography, and suggests that historians have often inadvertently adopted essentialised accounts of scientific and clinical culture, and assumed that those cultures necessarily exist in tension with one another. Historians have reinforced these assumptions by seeking out instances of conflict, while neglecting the many ways in which science and medicine have developed in concert with one another. In so doing, they have restricted their own ability to comment on the multiple forms that modern medicine has taken, and might take in future.

If you want to find out, the answer will be given in the 5th floor lecture room on 183 Euston Road (The Wellcome Bldg) in London on Wednesday 5 May at 5pm.

We’re talking about quite ordinary (but extraordinarily small) silicon chips that are made of a normal semiconductor material and produced by usual manufacturing methods. The chips can be used as intracellular sensors and the possibilites are endless — e.g., characterization, quantification and IRT monitoring of molecular processes at the single cell level.

This sounds like a promising route for molecular medicine. But it’s a potential nightmare for future medical museum curators. Good old steampunk medicine was about surgical instruments that operated on the level of visible organs. Now we’ve got a double problem: not only do we have to collect and preserve invisible cell-lines, but also take care of their invisible chips. 

Does this mean the end of medical museum collections as we know them? Has anybody got a good idea for how to collect, preserve and display these creatures?

Now I am beginning to think about a third volume in the ’series’ to catch up with new trends in science historiography. One of the most interesting issues — both from a museological and historiographical point of view — is how historians should deal with the growing avalanche of scientific digital documents.

I.e., how to preserve, utilise, and make sense of the enormous output of digitalised desk and laboratory data for the writing and displaying of contemporary history of science? Not just gigabytes of text documents (like manuscripts, electronic lab notebooks and emails), but also terabytes of quantitative experimental data — not to forget digitalised images and material things that embody such data (such a microarrays and biobanks).

Our guest blogger Martin Fenner wrote a very inspiring post about digital preservation a few weeks ago. “It’s surprising”, Martin concluded, ”that we have barely started to think about digital preservation”.

Another scholar who has thought about the problem is university archivist and library administration scientist Christopher Prom, currently a Fulbright Distinguished Scholar at the Centre for Archive and Information Studies, University of Dundee.

Prom is giving a talk here in Copenhagen next Thursday (4 March), titled ”Preserving the ‘Papers’ of 21st Century Science”, in which he will review the current state of work in preserving digital records and provide some suggestions regarding methods and tools that archives and others stakeholders can use to make sure that the electronic record of the 21st century will be accessible also in the 22nd. Here’s his abstract:

We cannot understand the full impact of scientific work without access to the correspondence, notes, and other materials that scientists generate on a daily basis. But how, in the digital era, can we best preserve the ‘papers’ generated by scientists? Such records are stored as mere electronic impulses, distributed across many locations, and written in formats that cannot be rendered without machines and software. As a result, rich historical sources, such as correspondence in email format, are at risk. Recent events in East Anglia demonstrate that such records are susceptible to hacking and misrepresentation in the short term. In the long term, they may be even more susceptible to loss through corruption or neglect.

The venue for Prom’s talk is the Niels Bohr Institute, Blegdamsvej 17; it starts at 2.15 pm. Copenhagen historian of physics Finn Aaserud organises the event.

Now the program has been finalised — and it looks very good! After a plenary discussion on ‘Schauplätze der Schönheit: Klinik, Kunst, Medien und Museen’ on Thursday evening, there follows two days of presentations, most of which seem to be very relevant for the future of medical and science museums:

• ‘Körperspuren im Deutschen Hygiene-Museum. Strategien und Objekte’ (Susanne Roeßiger, Deutsches Hygiene-Museum, Dresden)
• ‘Auf Biegen und Brechen. Zur (In)Formierung des Körpers’ (Stefan Rieger, Ruhr-Universität Bochum)
• ‘Der Körper und seine Teile. Vom Präparat zum transplantierten Organ’ (Katrin Solhdju, Zentrum für Literatur- und Kulturforschung, Berlin)
• ‘Vom Körper zum Maß. Zur Geschichte der Konfektionsgrößen’ (Daniela Döring, Humboldt-Universität zu Berlin)
• Vermessene Menschen. Vom Fingerabdruck bis zum Ganzkörperscan’ (Erika Feyerabend, BioSkop-Forum zur Beobachtung der Biowissenschaften e.V.)
• ‘Prothesen exponieren. Sichtbarkeiten neuer Technologien’ (Karin Harrasse, Kunsthochschule für Medien Köln)
• ‘Design in der Orthetik. Innovative Prinzipien der Körperanformung’ (Andreas Mühlenberend, resolutdesign; Hochschule Magdeburg-Stendal)
• ‘Wie sieht der bionische Mensch aus?’ (Friedrich Ditsch, Technische Universität Dresden)
• ‘”It’s a Material World”´: Situiertheit, Verkörperung und Materialität in der neueren Robotik’ (Jutta Weber, Universität Bielefeld)
• ‘Von der Nasen- zur Gesichtstransplantation: Zur Geschichte und Zukunft der kosmetischen Chirurgie’ (Sander L. Gilman, Emory University, Atlanta)
• ‘Science Fashion´: TechnoNaturen und deren alltagskulturellen Umdeutungen im System der Mode’ (Elke Gaugel, Akademie der Bildenden Künste, Wien)
• ‘Wie kommt die Seele ins Museum? Medizinische Museen und das Transzendentale’ (Robert Bud, Science Museum, London)
• ‘Den biomedizinischen Apparat ausstellen: Materialität und Digitalität in “Split + Splice” (Kopenhagen)’ (Susanne Bauer, Humboldt-Universität zu Berlin)
• ‘Die Schärfung des Blicks. Kunstinterventionen in anatomischen Sammlungen’ (Ingeborg Reichle, Berlin-Brandenburgische Akademie der Wissenschaften)
• ‘Körperwissen in der Kunst’ (Ute Meta Bauer, Massachusetts Institute of Technology, Boston)

As you can see, all presentations are in German — so the germanophilically challenged may have problems.

More here and here.

Part of my work, therefore, is going to conferences like this one, held in Copenhagen last week:

The conference was arranged by the Danish research center GNOSIS, and featured both neuroscientists and philosophers – as an attempt to bridge the disciplinary boundaries and maybe produce some kind of synergy.

The first day especially had that feeling. Themed under the headline ‘Brain Plasticity’ and featuring, among others, the English philosophical-minded neuroscientist Steven Rose, German phenomenological philosopher and psychiatrist Thomas Fuchs, and Danish biologist and anthropologist Andreas Roepstorff, there was a real feel of cross-disciplinary science communication. A science communication which was also a communication of the immense complexity of the brain and of the production of knowledge concerning it.

As Steven Rose pointed out, neuroscience is ‘data rich, but theory poor’, needing some theorizing on how best to manage the complexities of the huge amount of collected data. One common perspective to most of the talks at the conference were that the brain’s workings can best be understood viewed as a complex, irreducible and indeterminate, continuously developing process. This was conceptualized from both phenomenology, developmental systems theory (or autopoiesis, as Rose termed it), and biosemiotics – all in one way or the other emphasizing the brain as embodied (or the body as ‘embrained’, as someone smartly put it), and emphasizing the body’s embeddedness in the world (emworlded). Dichotomies and dualisms, determinacy and reductionism were (with maybe one exception) not only forcibly opposed, they were long left behind, it seemed.

But still there was a sense that, despite agreement on the general perspective, this did not solve the concrete methodological challenge of, for instance, going from correlates to causality, inducing from the particular to the common, or explaining the relationship between brain and mind/consciousness/awareness/attention etc. Neuroscience, it seems, brings new attention to a lot of old philosophical problems. The multidisciplinary collaborations within the field of neuroscience, and the demand for new theoretical developments and new conceptualizations, may not find a solution to these problems, but it sure sets the stage for interesting theoretical developments in the years to come.

As for the link to my project on successful aging, this development in neuroscience seems to run almost parallel to the overall development of the field of gerontology and aging research in the last couple of decades from around the time that the concept of successful aging was introduced. Many of the same philosophical problems are also seen in other parts of aging research than the parts including the neurosciences.

Aging research (as well as maybe most other fields in the health sciences?) is becoming a multidisciplinary field where dichotomies and dualisms between brain-mind, body-world, and individual-society are being tested and challenged.

 ’Successful aging’ in the neurosciences and the link to ‘cognitive enhancement’
In order to narrow the problem field, the project will look closely at how the notion of ‘successful aging’ has been understood and defined in the field of neuroscience in the last decades, and how ‘successful cognitive aging’ has played together with discussions — both in the scientific literature, in science policy documents and in general public discourse — about the possibility for so called ‘cognitive enhancement’ (‘neuro-enhancement’) [12][13][14][17]. Both in the scientific literature and in policy documents on ‘successful aging’ and ‘human enhancement’, the neurosciences are considered as the primary field of research; neuroscience also figures prominently in the corresponding public discourse [7][21][23], cf. [25]. The brain and cognition are ascribed significant cultural value in the emerging ‘knowledge society’; healthy cognitive abilities are considered necessary for a life-long contribution to the labour market and for well-being in everyday life, and not surprisingly some of the exponents for the notion of ‘knowledge society’ are also exponents for ‘converging technologies’ [17][21].

Current developments in the field of aging research also have strong discursive links to cognitive enhancement. As the aforementioned EU parliament study argues: “The growing problem of neurodegenerative diseases in ageing societies has turned research and development in therapeutic cognitive enhancers into a very dynamic field with significant resources” [21:26]. Likewise, in enhancement discussions special attention is being ascribed to cognitive enhancement: “’neuro/ brain enhancement’ as a research field stands at the centre of the CT [converging technologies] debate. It attracts the largest share of attention due to its plans to simulate and manipulate brain processes, which – if realized successfully – could directly affect our concepts of the human self and identity” [17:382], cf. [21][23][25]. Also here there may be a significant aspect of user-driven innovation: medications developed in research into age related diseases like Alzheimer’s disease is already being used by young, healthy individuals to (presumably) enhance their cognitive abilities [14][17][21], and, conversely, one could therefore expect that the market for cognitive enhancement may stimulate research in the prevention and treatment of age-related neurodegenerative diseases.

These interconnected arenas of aging research, enhancement discourse and general ideas about successful aging will be the focus point of this project. The point of departure is that the connection between the discussion about successful aging and the discussion about human enhancement has been overlooked in the scientific literature and that the two discourses are more closely related than usually presumed. Shedding light on the historical relation between the two notions both in the scientific and popular discourses will potentially have significant consequences for future research, for research politics and for the public understanding of successful aging.

References:
7. Kirk, H. (2008). Med hjernen i behold – Kognition, træning og seniorkompetencer. København: Akademisk Forlag.
12. Balling, G. (2002) (ed.). Homo Sapiens 2.0. Når teknologien kryber ind under huden. København: Gads Forlag.
13. Balling, G og Lippert-Rasmussen, K. (2006). Det menneskelige eksperiment. København: Museum Tusculanums Forlag.
14. Greely et al. (2008). Towards responsible use of cognitive-enhancing drugs by the healthy. Nature, 456, 702-705.
17. Beckert, B., Blümel, C and Friedewald, M (2007). Visions and realities in converging technologies. Innovation: The European Journal of Social Science Research, 20(4), 375-395.
21. European Parliament Science and Technology Options Assessment (2009). Human Enhancement Study. Awailable at http://www.europarl.europa.eu/stoa/publications/studies/stoa2007-13_en.pdf (14.08.09)
23. http://www.humanityplus.org/read/2009/07/human-enhancement-what-should-be-permitted-geneva-october-20-21-2009/ (14.08.09)
25. Dumit, Joseph (2004). Picturing Personhood. Brain Scans and Biomedical Identity. Princeton: Princeton University Press

The relation between ’successful aging’ and ‘human enhancement’
The project will particularly focus on an analysis of the possible connection between ideas about the prevention and treatment of age-related diseases, on the one hand, and the current merging discourse on ‘human enhancement’, on the other. Like ‘successful aging’, the notion of ‘human enhancement’ — including a large variety of different ideas about the future possibilities for technological improvements of human bodies — became widely spread in the 1980’s and 1990’s [11][12][13][14].

A preliminary survey of the literature indicates that the notions of ‘successful aging’ and ‘human enhancement’ often seem to appear together in the scientific literature and in medical and health policy documents. For example both the European Union (EU) and the National Science Foundation (NSF) have published reports that deal with so called ‘converging technologies’, usually defined as a convergence of nano-, bio-, info-, and cogno-sciences and technologies (NBIC). In such reports, the notion of ‘human enhancement’ is a central concept, around which the discussion of the aging population in the developed countries revolves [15][16][21], cf. also [17][18][19][20]. As a study commissioned by the EU Parliament says, “it is safe to say that a side effect of the fast-growing research and development into pharmaceuticals for age-related neurodegenerative diseases will be a number of new drugs which can be used for the enhancement of performance of young, healthy people.” [21:7]

Similarly, in a large number of websites and blogs published by organisations and individuals that support and promote the notion of ‘human enhancement’, the possibility for using such technologies as life extension devices and for delaying age-related physical and/or cognitive decline constitutes one of the central arguments for developing enhancement technologies [11][22]. Websites that express the opinions of the so called transhumanist (posthumanist) movement is one of the most vociferous exponents of this argument. Both these pro-enhancement advocates and science policy reports (like the EU parliament study and the NSF reports) emphasize the fact that the biomedical sciences, biotechnologies and medicotechnical technologies are increasingly producing new technologies capable of simultaneously enhancing the capacities of healthy people and treating diseases, especially age-related diseases [16][21][23]. Thus the discourse about ‘human enhancement’ and ‘successful aging’ are discursively intimately connected.

In addition, this integration of the ‘human enhancement’ and ‘successful aging’ discourses seem to have a strong element of user involvement. The strong ideological commitment to the integration between the two notions among individuals that view themselves as members of a loose ‘transhumanist’ intellectual movement is probably the best example of user involvement. It is unclear, however, to what extent the scientific community, the ‘transhumanist’ intellectual movement and the public at large differ with respect to an active commitment to integrating the two notions. However, I will suggest that the increasing use of performance-enhancing drugs in the general population (especially among young people) and the increasing dissemination of pro-enhancement policies and visions that challenge traditional views of the use of medicine both work in favour of a similar integration between the two notions.

Furthermore one might expect that the general and widely spread popular attitude to performance-enhancing drugs in Western cultures is an underlying Zeitgeist which supports the current political, scientific (and ethical) discussions about the integration of the two notions in the ‘transhumanist’ movement and among scientists. Finally, one might also expect that such popular attitudes will effect strategic market evaluations in the pharmaceutical industry and thus spill over to strategies for future drug pipelines. In all these respects, the integration of the notions of ‘human enhancement’ and ‘successful ageing’ may well be framed with reference to broader user involvement and user driven innovation (cf. [14][15][16][21][24]). These are preliminary hypotheses only, however, which need further empirical substantiation.

References:
11. Bostrom, N. (2005). A History of Transhumanist Thought. Journal of Evolution and Technology, 14(1).
12. Balling, G. (2002) (ed.). Homo Sapiens 2.0. Når teknologien kryber ind under huden. København: Gads Forlag.
13. Balling, G og Lippert-Rasmussen, K. (2006). Det menneskelige eksperiment. København: Museum Tusculanums Forlag.
14. Greely et al. (2008). Towards responsible use of cognitive-enhancing drugs by the healthy. Nature, 456, 702-705.
15. Roco, M and Bainbridge, W (2002) (eds.). Converging Technologies for Improving Human Performance. NSF/DOC-sponsored report. Awailable at http://www.wtec.org/ConvergingTechnologies/Report/NBIC_report.pdf. (29.05.2009)
16. Innovation: The European Journal of Social Science Research, 20(4) (December 2007). Special Issue: Converging Science and Technologies: Research Trajectories and Institutional Settings.
17. Beckert, B., Blümel, C and Friedewald, M (2007). Visions and realities in converging technologies. Innovation: The European Journal of Social Science Research, 20(4), 375-395.
18. Det Strategiske Forskningsråd (2006). Det aldrende samfund 2030 – Rapport fra Styregruppen for det strategiske fremsyn om det aldrende samfund 2030. Awailable at http://fi.dk/publikationer/2006/det-aldrende-samfund-2030-rapport-fra-styregruppen/det-aldrende-samfund-2030.pdf (29.05.2009)
19. Murphy, T. F.(1986). A cure for aging? The Journal of Medicine and Philosophy, 11(3): 237-255
20. Veatch, R.M. (1979). Life Span: the Hastings Center report on values and life-extending technologies. New York: Harper and Row.
21. European Parliament Science and Technology Options Assessment (2009). Human Enhancement Study. Awailable at http://www.europarl.europa.eu/stoa/publications/studies/stoa2007-13_en.pdf (14.08.09)
22. http://www.humanityplus.org/learn/philosophy/transhumanist-values (14.08.09)
23. http://www.humanityplus.org/read/2009/07/human-enhancement-what-should-be-permitted-geneva-october-20-21-2009/ (14.08.09)
24. Maher, Brendan (2008). Poll results: Look who’s doping. Nature, 452, 674-675

Below is the first part of the project description concerning the notion of successful aging. In two following parts I will first introduce the possible relation between successful aging and human enhancement, and then my attempt to narrow the project to cognitive aspects of ageing and cognitive enhancement. Comments to one or all three parts are much appreciated.

The genealogy of the notion of ’successful aging’
At present there is much focus on the notion of successful aging (healthy aging, optimal aging) in Denmark and other developed countries. The increasing life expectancy of the population in combination with low birth rate and low rate of immigration gives rise to both political and economic concerns about the future maintenance of the living standards for an aging workforce. The increasing number of elderly people gives rise to new demands for developing new knowledge about how individuals can live a healthy life and remain healthy, even in old age.

The notion of ‘successful aging’ is not new. It can in fact be traced back to at least the 1960’s and became ubiquitous in the field of aging research in the 1980′ and 1990’s [1][2][3][4][5]. The dissemination of the notion is connected to a development trend in aging research, whereby scientists gradually changed their understanding of aging as a research object for gerontological/geriatric research. From primarily being concerned with the treatment of diseases in later part of a life course to an increased focus on disease prevention and to a broader public health oriented approach to aging involving several different scientific fields, also beyond the biomedical sciences [4][6], cf. [7].

The aim of this project is to undertake a genealogical study[8][9] of the development of the notion of successful aging from the increased focus on prevention in the middle of the 1980’s until today. The literature on the subject is sparse, consisting of a few short chapters with an overview of the historical development of age research, cf. [6][10]. A more detailed historical study of this development based on the primary literature (scientific articles, textbooks, policy documents, etc.), is supposedly going to produce a deeper and better understanding of the notion of successful aging, which in turn will help qualify the current scientific and public discussions about the prevention and treatment of age-related diseases. The study will thus hopefully also help identify some of the conditions that may influence future understandings of what ‘successful aging’ is and the ways in which the future research in the field might develop.

References:
1. Williams, Richard H., and Wirth, Claudine, G. (1965). Lives through the years: styles of life and successful aging. New York: Prentice-Hall.
2. Rowe, J. W. and Kahn, R. L. (1987). Human Aging: Usual and Successful. Science, 237: 143-149.
3. Rowe, J. W. and Kahn, R. L. (1998). Successful aging. USA: Pantheon Books.
4. Baltes, P. B. and Baltes, M. M. (1990) (eds.). Successful aging: Perspectives from the behavioral sciences. Cambridge, UK: Cambridge University Press.
5. Bond, L. A., S. J. Cutler, and A. Grams (1995). Promoting Successful and Productive Aging. Thousand Oaks, CA: Sage Publications, Inc.
6. Amstrup, K og Poulsen, I. (2007). Geriatri – en tværfaglig udfordring. København: Munksgaard Danmark.
7. Kirk, H. (2008). Med hjernen i behold – Kognition, træning og seniorkompetencer. København: Akademisk Forlag.
8. Villadsen, K. (2006). Genealogi som metode: fornuftens tilblivelseshistorier. Kaspar Villadsen & Ole Bjerg (2005) (eds.). Sociologiske metoder: Fra teori til empiri i kvalitative og kvantitative studier. Frederiksberg: Samfundslitteratur.
9. Foucault, Michel (1992). The archaeology of knowledge. London: Routledge.
10. Bengtson, V.L. and Schaie, K.W (1999) (eds.). Handbook of Theories of Aging. New York: Springer Publishing Company, inc.

See also interview in San Francisco Chronicle online. She could have been part of our Design4Science exhibition last spring.

(Thanks to Jessica for the tip)